The actor was reportedly transported to a hospital but has not suffered serious injuries.
According to TGR Rai Sardegna, the US actor was riding his bike at Costa Corallina when he was involved in a collision with a car on Tuesday morning.
A picture from La Nuova suggest that the 57-year-old actor was involved in the incident while riding on a motorway, leaving the car’s windscreen smashed.
Clooney was said to be caught off guard by the car when it suddenly turned and changed direction outside a hotel.
The driver of the car reportedly helped the actor while waiting for the 118 ambulance to arrive.
The publication added that the actor was taken to the emergency room following reported trauma to the pelvis and bruises to one leg and arm but has not been seriously injured.
In hospital he was joined by wife Amal and it has been reported that the pair left together in a private car
Clooney, wife Amal and their two children are living in Sardinia for the summer where he is believed to be filming his new TV series, Catch 22.
He is reportedly directing, producing and starring in the mini-series based on Joseph Heller’s acclaimed novel.